The aim of this paper is to propose a lifetime prediction method for threaded connections. The example discussed here is a drillstring connection used in the oil and gas industry. The method is based on a mechanical analysis performed either with finite elements or a closed-form solution described in a companion paper, and a fatigue analysis using the Dang Van criterion which has been extended to finite life domain. The mechanical analysis provides the stabilized stress path and the fatigue analysis provides the fatigue life. Fatigue tests have been performed on small scale threaded connections in order to validate the methodology. The comparisons with the predictions show the difficulties to estimate the fatigue life on structures presenting high stress gradient due to scale effects.