Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Stefano Crosignani; Patrick Bingham; Pauline Bottemanne; Hélène Cannelle; Sandra Cauwenberghs; Marie Cordonnier; Deepak Dalvie; Frederik Deroose; Jun Li Feng; Bruno Gomes; Samantha Greasley; Stephen Kaiser; Manfred Kraus; Michel Negrerie; Karen Maegley; Nichol Miller; Brion Murray; Manfred Schneider; James Soloweij; Albert Stewart; Joseph Tumang; Vince Torti; Benoit van den Eynde; Martin Wythes

doi:10.1021/acs.jmedchem.7b00974

Journal Articles Journal of Medicinal Chemistry Year : 2017

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

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Stefano Crosignani

Function : Correspondent author
PersonId : 1030353

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iTeos Therapeutics

Patrick Bingham

Function : Author

Pfizer

Pauline Bottemanne

Function : Author

iTeos Therapeutics

Hélène Cannelle

Function : Author

iTeos Therapeutics

Sandra Cauwenberghs

Function : Author

iTeos Therapeutics

Marie Cordonnier

Function : Author

iTeos Therapeutics

Deepak Dalvie

Function : Author

Pfizer

Frederik Deroose

Function : Author

Asclepia Outsourcing Solutions

Jun Li Feng

Function : Author

Pfizer

Bruno Gomes

Function : Author

iTeos Therapeutics

Samantha Greasley

Function : Author

Pfizer

Stephen Kaiser

Function : Author

Pfizer

Manfred Kraus

Function : Author

Pfizer

Michel Negrerie

Function : Author
PersonId : 906653

iTeos Therapeutics

Laboratoire d'Optique et Biosciences

Karen Maegley

Function : Author

Pfizer

Nichol Miller

Function : Author

Pfizer

Brion Murray

Function : Author

Pfizer

Manfred Schneider

Function : Author

iTeos Therapeutics

James Soloweij

Function : Author

Pfizer

Albert Stewart

Function : Author

Pfizer

Joseph Tumang

Function : Author

Pfizer

Vince Torti

Function : Author

Pfizer

Benoit van den Eynde

Function : Author
PersonId : 837644

Université Catholique de Louvain = Catholic University of Louvain

Martin Wythes

Function : Correspondent author
PersonId : 1030354

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Pfizer

Domains

Biochemistry, Molecular Biology

Aurélien Arnoux : Connect in order to contact the contributor

https://polytechnique.hal.science/hal-01760561

Submitted on : Friday, April 6, 2018-2:36:11 PM

Last modification on : Thursday, August 1, 2024-1:48:06 PM

Dates and versions

hal-01760561 , version 1 (06-04-2018)

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HAL Id : hal-01760561 , version 1
DOI : 10.1021/acs.jmedchem.7b00974

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Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, Hélène Cannelle, Sandra Cauwenberghs, et al.. Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. Journal of Medicinal Chemistry, 2017, 60 (23), pp.9617 - 9629. ⟨10.1021/acs.jmedchem.7b00974⟩. ⟨hal-01760561⟩

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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

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