Toward simple in silico experiments for drugs administration in some cancer treatments - École polytechnique Access content directly
Conference Papers Year : 2021

Toward simple in silico experiments for drugs administration in some cancer treatments

Abstract

We present some "in silico" experiments to design combined chemo-and immunotherapy treatment schedules. We introduce a new framework by combining flatness-based control, which is a model-based setting, along with model-free control. The flatness property of the used mathematical model yields straightforward reference trajectories. They provide us with the nominal open-loop control inputs. Closing the loop via model-free control allows to deal with the uncertainties on the injected drug doses. Several numerical simulations illustrating different case studies are displayed. We show in particular that the considered health indicators are driven to the safe region, even for critical initial conditions. Furthermore, in some specific cases there is no need to inject chemotherapeutic agents.
Fichier principal
Vignette du fichier
Cancer21.pdf (1.1 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03299417 , version 1 (26-07-2021)
hal-03299417 , version 2 (10-11-2021)

Identifiers

Cite

Michel Fliess, Cédric Join, Kaouther Moussa, Seddik M Djouadi, Mohamed W Alsager. Toward simple in silico experiments for drugs administration in some cancer treatments. BMS 2021 - 11th IFAC symposium on Biological and Medical Systems (BMS 2021), Sep 2021, Ghent, Belgium. ⟨10.1016/j.ifacol.2021.10.263⟩. ⟨hal-03299417v2⟩
332 View
233 Download

Altmetric

Share

Gmail Facebook X LinkedIn More