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Journal Articles European Journal of Organic Chemistry Year : 2018

A Passerini/Michael Pathway towards Butyrolactones

Abstract

The Passerini adducts of aromatic aldehydes may act as nucleophiles in Michael additions with acrylonitrile. The reaction proceeds together with hydrolysis of the ester. The resulting γ‐hydroxynitrile may be cyclized under acidic conditions to afford a three‐steps synthesis of γ‐butyrolactones from isocyanides.
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hal-02095101 , version 1 (14-01-2024)

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Shuanglong Jia, Laurent El Kaim. A Passerini/Michael Pathway towards Butyrolactones. European Journal of Organic Chemistry, 2018, 2018 (46), pp.6457-6464. ⟨10.1002/ejoc.201800958⟩. ⟨hal-02095101⟩
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