A short synthesis of (±)-13-deoxyserratine - École polytechnique Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2002

A short synthesis of (±)-13-deoxyserratine

Abstract

A short and efficient total synthesis of (±)-13-deoxyserratine (3) features a highly stereoselective intramolecular Pauson-Khand reaction of 1 and a cascade of radical cyclizations starting with the amidyl radical 2. The desired alkaloid 3 was thus obtained in ten steps in an overall yield of 12 %. THP = tetrahydropyranyl, TBS = tert-butyldimethylsilyl.

Dates and versions

hal-00954852 , version 1 (18-03-2014)

Identifiers

Cite

J. Cassayre, Fabien Gagosz, Samir Z. Zard. A short synthesis of (±)-13-deoxyserratine. Angewandte Chemie International Edition, 2002, 41 (10), pp.1783-1785. ⟨10.1002/1521-3773(20020517)41:10<1783::AID-ANIE1783>3.0.CO;2-I⟩. ⟨hal-00954852⟩
101 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More