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Journal Articles Chemistry - A European Journal Year : 2014

Predicting New Ugi-Smiles Couplings: A Combined Experimental and Theoretical Study

Abstract

Following our previous mechanistic studies of multicomponent Ugi-type reactions, theoretical calculations have been performed to predict the efficiency of new substrates in Ugi-Smiles couplings. First, as predicted, 2,4,6-trichlorophenol experimentally gave the corresponding aryl-imidate. Theoretical predictions of nitrosophenols as good acidic partners were then successfully confirmed by experiments. In the latter case, the reaction offers a new access to benzimidazoles.

Dates and versions

hal-01057795 , version 1 (25-08-2014)

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Romain Ramozzi, Nicolas Chéron, Laurent El Kaim, Laurence Grimaud, Paul Fleurat-Lessard. Predicting New Ugi-Smiles Couplings: A Combined Experimental and Theoretical Study. Chemistry - A European Journal, 2014, 20 (29), pp.9094-9099. ⟨10.1002/chem.201400336⟩. ⟨hal-01057795⟩
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