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Journal Articles ALTEX - Alternatives to Animal Experimentations Year : 2015

Integrated Testing Strategies (ITS) for safety assessment.

Patrick Hayden
  • Function : Author
Christa Hegele-Hartung
  • Function : Author
Joanna Jaworska
  • Function : Author
Jon Lalko
  • Function : Author
Robert Landsiedel
  • Function : Author
Annette Mehling
  • Function : Author
Jonathan W Pitchford
  • Function : Author
Andreas Schepky
  • Function : Author
Dirk Weisensee
  • Function : Author


Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and "Good ITS Practices".
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hal-01127740 , version 1 (08-03-2015)



Costanza Rovida, Nathalie Alépée, Anne M Api, David A Basketter, Frédéric y Bois, et al.. Integrated Testing Strategies (ITS) for safety assessment.. ALTEX - Alternatives to Animal Experimentations, 2015, 32 (1), pp.25-40. ⟨10.14573/altex.1411011⟩. ⟨hal-01127740⟩
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