A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β-Unsaturated Trifluoromethyl Ketones - École polytechnique Access content directly
Journal Articles Organic Letters Year : 2015

A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β-Unsaturated Trifluoromethyl Ketones

Samir Z. Zard
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Abstract

A convergent synthesis of trifluoromethyl ketones and alpha beta-unsaturated trifluoromethyl ketones is described, starting with aliphatic iodides and dithiocarbonates (xanthates) and exploiting both the alpha- and beta-fragmentations of a sulfonyl radical. The transformation initially furnishes the ketones in a masked enol carbonate form, from which they can be easily regenerated.
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hal-01186604 , version 1 (25-08-2015)

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Lucile Anthore, Samir Z. Zard. A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β-Unsaturated Trifluoromethyl Ketones. Organic Letters, 2015, 17 (12), pp.3058-3061. ⟨10.1021/acs.orglett.5b01344⟩. ⟨hal-01186604⟩
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