A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids - École polytechnique Access content directly
Journal Articles Organic Letters Year : 2016

A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Abstract

A radical based synthesis of a broad variety of protected enantiopure alpha-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-a-amino acids ideally equipped for native chemical ligation.
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hal-01323304 , version 1 (30-05-2016)

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Shi-Guang Li, Fernando Portela-Cubillo, Samir Z. Zard. A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids. Organic Letters, 2016, 18 (8), pp.1888-1891. ⟨10.1021/acs.orglett.6b00656⟩. ⟨hal-01323304⟩
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