Piperazine as Leaving Group in A3 Adducts: Fast Access to Alkynyl Indoles - École polytechnique Access content directly
Journal Articles SYNLETT Year : 2016

Piperazine as Leaving Group in A3 Adducts: Fast Access to Alkynyl Indoles

Abstract

The A3 coupling between N-ethylpiperazine and electron-rich aromatic aldehydes forms adducts that may be easily used as electrophiles towards electron-rich heterocycles such as indoles. The removal of the piperazine moiety is triggered by the addition of 1,2-dibromoethane. Overall, the reaction provides efficient access to alkynyl indoles and pyrroles.
No file

Dates and versions

hal-01444342 , version 1 (23-01-2017)

Identifiers

Cite

Mansour Dole Kerim, Laurent El Kaim. Piperazine as Leaving Group in A3 Adducts: Fast Access to Alkynyl Indoles. SYNLETT, 2016, 27 (10), pp.1572-1576 ⟨10.1055/s-0035-1561396⟩. ⟨hal-01444342⟩
119 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More