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Journal Articles Journal of Organic Chemistry Year : 2018

Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides

Abstract

An intramolecular aryne Diels-Alder reaction with a furan moiety was applied to the synthesis of dihydrobenzo[ de]isochromenes as intermediates toward naphthalimides. After oxidation, this method offers an efficient approach for the synthesis of substituted naphthalimides, which showed potent cytotoxic activity against HT-29 human cancer cell line.
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hal-02091716 , version 1 (06-04-2019)

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Sébastien Prevost, Ambre Dezaire, Alexandre Escargueil. Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides. Journal of Organic Chemistry, 2018, 83 (8), pp.4871-4881. ⟨10.1021/acs.joc.8b00531⟩. ⟨hal-02091716⟩
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