TiCl4-Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions - École polytechnique Access content directly
Journal Articles Synthesis: Journal of Synthetic Organic Chemistry Year : 2018

TiCl4-Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions

Abstract

The isocyanide insertion into sulfanyl-phthalides under Lewis acid conditions is reported with full details. This sequential three-component reaction affords a new straightforward and highly convenient method for the preparation of 3-amino-4-sulfanyl isocoumarins, the potential of which is still unexplored.
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hal-02095068 , version 1 (10-04-2019)

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Sudipta Ponra, Aude Nyadanu, Sylvie Maurin, Laurent El Kaim, Laurence Grimaud, et al.. TiCl4-Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions. Synthesis: Journal of Synthetic Organic Chemistry, 2018, 50 (06), pp.1331-1342. ⟨10.1055/s-0036-1591733⟩. ⟨hal-02095068⟩
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