Bulges in left-handed G-quadruplexes - École polytechnique Access content directly
Journal Articles Nucleic Acids Research Year : 2021

Bulges in left-handed G-quadruplexes


G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
Fichier principal
Vignette du fichier
gkaa1259.pdf (4.45 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-03188426 , version 1 (06-10-2021)




Poulomi Das, Khac Huy Ngo, Fernaldo richtia Winnerdy, Arijit Maity, Blaž Bakalar, et al.. Bulges in left-handed G-quadruplexes. Nucleic Acids Research, 2021, 49 (3), pp.1724-1736. ⟨10.1093/nar/gkaa1259⟩. ⟨hal-03188426⟩
85 View
40 Download



Gmail Mastodon Facebook X LinkedIn More