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Dynamic compensation and homeostasis: a feedback control perspective

Abstract

"Dynamic compensation" is a robustness property where a perturbed biological circuit maintains a suitable output [Karin O., Swisa A., Glaser B., Dor Y., Alon U. (2016). Mol. Syst. Biol., 12: 886]. In spite of several attempts, no fully convincing analysis seems now to be on hand. This communication suggests an explanation via "model-free control" and the corresponding "intelligent" controllers [Fliess M., Join C. (2013). Int. J. Contr., 86, 2228-2252], which are already successfully applied in many concrete situations. As a byproduct this setting provides also a slightly different presentation of homeostasis, or "exact adaptation," where the working conditions are assumed to be "mild." Several convincing, but academic, computer simulations are provided and discussed.
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Dates and versions

hal-01684422 , version 1 (15-01-2018)
hal-01684422 , version 2 (15-01-2018)

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Michel Fliess, Cédric Join. Dynamic compensation and homeostasis: a feedback control perspective. [Research Report] Ecole polytechnique X. 2018, pp.1-22. ⟨hal-01684422v2⟩
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